An Immunohistochemical study of CD83 positive dendritic cell density in human benign and malignant uterine specimens

Introduction and Aim: Dendritic cells (DCs) are heterogenous group of accessory that function as specialized forms antigen-presenting in human body. A thorough knowledge the DC population uterus, especially CD83 would be very useful for an effective understanding immune protection endometrium during different phases menstrual cycle pathological conditions uterus. Materials Methods: prospective study was conducted a tertiary care referral medical college hospital South India. Women age 35 to 50 years, who underwent hysterectomy were included study. Immunohistochemical on presence mature CD83+DCs carried out processed uterine specimens. The number cells/20 high power fields each specimen calculated reviewed by two independent reviewers. Results: About 43 specimens obtained from patients undergoing benign malignant uterus Fibroid most common indication hysterectomy. minimum maximum DCs 12 720 per 20 HPF respectively, with overall mean 109.28. amongst 1.2 22.65 HPF, P value 0.0001. Conclusion: Mature dendritic seen abundance pre-malignant tissues reduction CD83+ observed proliferative secretory endometrium.